las

Welcome all seeking refuge from low carb dogma!

“To kill an error is as good a service as, and sometimes even better than, the establishing of a new truth or fact”
~ Charles Darwin (it's evolutionary baybeee!)

Sunday, April 22, 2018

The Cause of the Obesity Epidemic


I couldn't help but snap a picture of this at the playground yesterday.  Asylum regulars will recognize the true cause of the obesity epidemic in this picture. 

Babies In Ketosis


April 2018 Update:



Here in the year 2018, it's fair to say that #Paleo is pretty much over. Nothing tells us this more succinctly than a quick trip over to Mark's Daily Apple, a website I rarely frequent these days. I'd heard rumors that Mark had "gone keto" ... given the seemingly meteoric rise of #Keto of late, is anyone really surprised?  This is the same man who developed the "more addictive than crack" P90X recovery drink and other things, 


Ever the businessman (can't fault him for that), Mark seems to have transitioned from using his blog to sell paleo/primal-related books (did he ever find a proper ghostwriter for his wife's book?) to selling over-priced avocado oil products.   The whole "primal" thing is about as downplayed as possible for someone whose signature product is The Primal Blueprint, can be.    Poor Grok.  Now it's Keto Reset time!  Can these marketeers PLEASE make up their minds?  

When someone doesn't "take" to a so-called keto diet, it's always "they probably weren't fat adapted yet".  This mythical and magical fat-adaptation has been purported to take 6 months to a year to reach full nirvana-level.  But now?  Why you can reboot your metabolism (whatever that means!) in just three weeks, and be a fat burning beast evermore!  Kewl!!

What brought this post update about?  I came across a link to a recent post by Sisson addressing What Happens “After Keto”?
"Google searches for this question have shot up in recent weeks. I’m not surprised. An unprecedented number of people went keto in January purely as a quick weight loss hack, and now they’re looking to transition off of “this weird diet.” ...
Well duh.  The best indicator of the fad-factor of a diet may well be the January bump it receives in Google trends. 


Keto is a reset (a Keto Reset (if you're going to buy this, why not use my affiliate link?), even). It’s a return to the ancestral metabolic state, the metabolic state we were born into (newborns are filthy with ketones, even on their relatively sweet mother’s milk diet). Keto happens really easily in humans compared to other animals. You go 12 hours without eating and then wake up in the morning? You’ll have detectable ketones on your breath. It’s almost like we’re made for it. "endquote
So I tweeted out a tongue in cheek response.  Basically, if you even believe in some sort of rebooting/resetting of your metabolism to its infantile state, why stop with diet and metabolism?  The more one thinks about this, the more absurd the "babies are in ketosis" argument becomes.  Read on.  Don't fall for this!!

As to Mark's contention that "it's like we're almost made for it" ... there's a table at his own link that shows that as a species outside of infancy and pregnancy, compared to rats, we're actually "not so much".   Mark knows this.  Staying in therapeutic ketosis as an adult (not this nutritional gimmick nonsense) is rather difficult for most people.  I've been reminded recently that for some, even a leaf of spinach or the taste of artificial sweeteners can be enough to banish one from planet Keton (coined by @LouSchuler on Twitter).  I won't even quibble (again from conversation on Twitter) with evidence that we aren't "born in ketosis".  

As the recent Gardner-led, partially NuSI funded study demonstrated, modern American humans -- for various reasons -- have difficulty adhering to extreme diets.  This is not evidence against the *potential* for various diets to be effective, nor is it evidence that following such diets is harmful for the long term.  But it is evidence that as a dietary prescription of sorts, neither is going to garner much success in the general population.  But one last thing before I go on this point.  I've mentioned this before, and I'll mention it again.  We have BILLIONS of humans who have thrived on very low fat diets throughout their lives, for generations.  We just don't have anything near this for low carb diets, let alone keto versions.  In his article, Sisson says the following:
Studies as long as five years (link to full text) show no negative side effects of long-term ketogenic dieting, so, provided you do it right (no salami and cream cheese keto diets), I see no reason not to continue.
Look at the full text I provided.  This was a case study on THREE young adults with GLUT-1 deficiency.  Two who were normal weight at baseline lost a little bit of weight in the form of fat.  One who was underweight at baseline gained weight:  this individual grew 1.5 cm indicating she wan't fully grown at baseline, and gained more fat than weight (gained 1.5 kg overall, 2kg fat, thus lost 0.5 kg FFM).  The authors mention that the results here are in contrast to those seen in children treated for epilepsy because of full bone mineralization at baseline.  Perhaps, at the very least, there should be extreme caution for growing children or teens to embark on a keto diet!   I see no reason to trust Mark Sisson on the long-term appropriateness of any diet.  






Friday, April 13, 2018

Bio-HACK-ing Chronicles Ep.2: Maybe Jimmy Moore Has Hepatic Encephelopathy


No ... this blog will not become all Jimmy Moore, all the time.  I do have some posts in the works that just need some polish ... including one on the study Ted Naiman bases his 3:1 ratios of grams protein to fat that Jimmy was following.  That said, I can't help but put together a few comments on the Drama Llama supreme's latest n=1.


This Episode's n=1 bioHACK:   
  • 7 days of "Carnivore" , High Protein (mostly meat)
  • 3:1 grams protein:grams fat.   
  • 1.5 grams of protein per pound of lean body mass equaled 270 g protein:90 g fat.   (if you use 40% body fat, that puts his current weight at 300 ... )


RESULT:  Fail. 
If you listen at the 43 minute mark of this episode of The Keto Savage podcast, you'll see that it was Jimmy's every intention for this TO fail.

The purpose of biohacking is SUPPOSED to be about seeking out ways to improve one's overall health ... to achieve meaningful goals.  This nonsense of seeing what happens to his glucose and ketone readings here and there, ignore body weight entirely, get two insulin readings, estimate portions, etc. is all just nonsense.   He's not healing anything.  He's playing around with whatever healthy function he has left for social media likes and podcast downloads so he can sell keto stuff to earn affiliate dollars.  Sad really.

Tuesday, March 27, 2018

Bio-HACK-ing Chronicles Ep.1: What's with Jimmy Moore's HCT & Hb?


I've decided to chronicle some of the biohacking madness going on out there here on the blog.   I'm not sure if this helps anyone, but at least it will preserve some of it for posterity.   So this will randomly include publicly shared results of various "hacks" -- dietary or otherwise.

First up -- who else? LOL -- Jimmy Moore.  Fresh off his second 7-day fast in three weeks, Jimmy continues focusing on all the wrong things instead of actual improvements in things known to improve health.  Apparently low carb is/wasn't enough for Jimmy Moore, so he adopted an extreme version of a keto diet.  This worked swimmingly for a year until he stopped reporting his weight at the end of the year.  He rapidly regained the 80 re-lost pounds and embarked on his first extended fast in the fall of 2015.  That went so well he tried (unsuccessfully) to forego food for the entirety of January 2016, only to balloon up even further.  Forget the scale, I won't even post images, you've seen them all.  He is a profoundly unhealthy man despite cherry-picked biomarkers that appear to indicate otherwise.  

Jimmy Moore is obsessed with measuring ketones (everywhichway, apparently, but up the bum -- is an anal ketone test far behind?  LOL) and blood sugar.  Unless you are using insulin to control diabetes and/or concerned about ketoacidosis, or are on a therapeutic ketogenic diet for something like epilepsy, incessant glucose and (especially) ketone monitoring is pretty meaningless and probably neuroses-inducing in many.   

BOTTOM LINE:  When ANYONE (other than an IDDM) doesn't eat for a few days, their blood sugars will go down and their ketone levels will go up.  So big whoop that this happened to Jimmy Moore.  

I'm rather more interested in this:



Saturday, March 24, 2018

Keto will Change Your Life!


Just have to share, this ABSOLUTELY HILARIOUS clip from a recent episode of NCIS Los Angeles (Season 9, Episode 15, around 13 min in). 

Shared on Twitter and Facebook if you want to share on social media!

Monday, March 12, 2018

The Manhattan Project of Nutrition That Wasn't



With publication of the results of the second of the "Original 3" NuSI funded studies, I'm finally getting around to publishing up this post (and perhaps a second one shortly) regarding the Nutrition Science Initiative (NuSI), founded in 2012 by Peter Attia, MD and "science journalist" Gary Taubes. Bottom line ... for NuSI, it was "all over but the crying" a couple of years ago now. 







Monday, March 5, 2018

Dietary Energy Density and Incidence of Diabetes in the Women's Health Initiative


Summary:

In the Women's Health Initiative, a 2017 analysis of the energy density of baseline diets, stratified to quintiles, revealed several correlative components of an energy dense diet (comparing the top quintile (Q5) to the bottom (Q1).  The energy density, in kcal/gram of food, nearly doubled in Q5 vs. Q1 corresponding to a nearly 50% increase in caloric intake.  The dietary components correlating with this are:

  • Fat:  Fat content is by far and away the greatest contributing factor to consuming an energy dense diet.   Absolute intake more than doubled (2.5X) from Q1 to Q5, and comprised roughly 90% of the increased caloric intake.
  • Animal Protein:  As protein intake from plant sources remained relatively constant, animal protein intake increased by 40% resulting in an increase in total protein of 25%.  Therefore animal foods are a considerable contributor to increased energy density of the diet.
  • Added Sugars:  Added sugar comprised 11% of caloric intake across the quintiles, however absolute added sugar increased almost 50%.  
  • Carbohydrate:  Total carbohydrate intake is not associated with increased energy density of the diet.  Increases in added sugars were offset by reduction in other carbohydrates so that absolute intake remained constant.  Thus as a percentage of the caloric intake, carbohydrate declined significantly.
  • The macro percent composition of the least energy dense diets was P/F/C of 18/26/59, while the percents were 16/45/41 for the most energy dense diets.
The near doubling of energy density is associated with an (adjusted) roughly 25% increase in the risk of developing diabetes.



Monday, February 26, 2018

Maybe the Solution Lies in Making the Food Industry Our Friends


In our current times of rising obesity and chronic disease rates in the developed world (and spreading globally), I see a handful of "usual suspects" upon which the phenomenon is blamed:

  • The food industries
  • Governments and guidelines
  • The entertainment industries 
  • The general health and beauty industries
  • The diet and fitness industries 
By far and away, in no particular order, the two at the top of the list shoulder most of the blame.  You know the story by now.  Ancel Keys .... McGovern Committee ... Low fat dietary guidelines ... we got fat because CARBS and INSULIN!!!

Thursday, February 15, 2018

Keto Klarity Karma ~ All Aboard the Jimmy Moore Livin La Vida Low Carb Drama Express!!


You are forewarned:  


This post contains no science.  It's a bit of gossip and speculation, and simply exposing and documenting some goings on in the LLVLC and related worlds this past year and in recent times. There's no TL,DR.  But c'mon, I KNOW some of you are here at the Asylum for this stuff.  πŸ‘ΏπŸ˜ˆπŸ˜ˆπŸ˜‡πŸ˜‡

While it is possibly a royal waste of my time, I do think it is important to keep shining a light on the source of so much information on the internet.  Whether it's from Jimmy Moore directly, or through the filters of his podcasts, or the reality that he's an internationally best selling author of health and nutrition books, his level of disinformation cannot go unchecked. 

Lastly, much of this was written train of thought when it was going down.  I did my best to change tenses and edit out repetition in an effort to actually publish.  I make no promises. πŸ˜€


Friday, January 26, 2018

All Roads Lead Through Krebs ~ True Keto Clarity & The Truth About Fat Burning Beasts

Summary:


BUMPED January 26, 2018

This post was written around three and a half years ago, and through some bizarre twist of dietary fate, somehow ketogenic diets are still trending on Google for everything from weight loss to hang nails.  So I thought I'd bump this post which was my attempt at dispelling some myths regarding ketosis and the role of dietary protein in the mix.  

In the end, and some of these points are not made specifically in this post but I'll make them here:
  • Carbohydrate restriction is the greatest determinant of ketogenesis 
  • Protein (various amino acids) can feed into the Krebs Cycle and attenuate the reduction in oxaloacetate that favors ketogenesis from fatty acids.
  • Ketogenesis represents a conversion of fat energy to ketone energy but it is not evidence of the ultimate usage of that energy.  
  • Like glucose, ketones will be burned for energy before fatty acids, so ketogenesis is not an indicator of actual fatty acid oxidation ("fat burning")
  • Type 1 Diabetics have elevated ketogenesis and gluconeogenesis.  This is evidence that gluconeogenesis does not "kick one out of ketosis"!
  • The availability of gluconeogenic substrates is an unlikely cause for any elevation in blood glucose levels by stimulating gluconeogenesis.
  • Ketogenesis occurs in all of us at low levels, moreso when fasted and in caloric deficit.  But significant levels generally require significant metabolic dysregulation (e.g. Type 1 diabetes) or carbohydrate restriction.  The exception to this is high intake of MCTs.
  • Exogenous ketones are not "ketogenic" any more than eating a banana is "gluconeogenic".  Both simply directly supply the energetic substrate vs. creating it in the body.